Large-Scale Detection of Non-Technical Losses in Imbalanced Data Sets

Non-technical losses (NTL) such as electricity theft cause significant harm to our economies, as in some countries they may range up to 40% of the total electricity distributed. Detecting NTLs requires costly on-site inspections. Accurate prediction of NTLs for customers using machine learning is therefore crucial. To date, related research largely ignore that the two classes of regular and non-regular customers are highly imbalanced, that NTL proportions may change and mostly consider small data sets, often not allowing to deploy the results in production. In this paper, we present a comprehensive approach to assess three NTL detection models for different NTL proportions in large real world data sets of 100Ks of customers: Boolean rules, fuzzy logic and Support Vector Machine. This work has resulted in appreciable results that are about to be deployed in a leading industry solution. We believe that the considerations and observations made in this contribution are necessary for future smart meter research in order to report their effectiveness on imbalanced and large real world data sets.Comment: Proceedings of the Seventh IEEE Conference on Innovative Smart Grid Technologies (ISGT 2016

Large-Scale Detection of Non-Technical Losses in Imbalanced Data Sets

Non-technical losses (NTL) such as electricity theft cause significant harm to our economies, as in some countries they may range up to 40% of the total electricity distributed. Detecting NTLs requires costly on-site inspections. Accurate prediction of NTLs for customers using machine learning is therefore crucial. To date, related research largely ignore that the two classes of regular and non-regular customers are highly imbalanced, that NTL proportions may change and mostly consider small data sets, often not allowing to deploy the results in production. In this paper, we present a comprehensive approach to assess three NTL detection models for different NTL proportions in large real world data sets of 100Ks of customers: Boolean rules, fuzzy logic and Support Vector Machine. This work has resulted in appreciable results that are about to be deployed in a leading industry solution. We believe that the considerations and observations made in this contribution are necessary for future smart meter research in order to report their effectiveness on imbalanced and large real world data sets

<i>In vitro</i> antiviral activity of the anti-HCV drugs daclatasvir and sofosbuvir against SARS-CoV-2, the aetiological agent of COVID-19

BackgroundCurrent approaches of drug repurposing against COVID-19 have not proven overwhelmingly successful and the SARS-CoV-2 pandemic continues to cause major global mortality. SARS-CoV-2 nsp12, its RNA polymerase, shares homology in the nucleotide uptake channel with the HCV orthologue enzyme NS5B. Besides, HCV enzyme NS5A has pleiotropic activities, such as RNA binding, that are shared with various SARS-CoV-2 proteins. Thus, anti-HCV NS5B and NS5A inhibitors, like sofosbuvir and daclatasvir, respectively, could be endowed with anti-SARS-CoV-2 activity.MethodsSARS-CoV-2-infected Vero cells, HuH-7 cells, Calu-3 cells, neural stem cells and monocytes were used to investigate the effects of daclatasvir and sofosbuvir. In silico and cell-free based assays were performed with SARS-CoV-2 RNA and nsp12 to better comprehend the mechanism of inhibition of the investigated compounds. A physiologically based pharmacokinetic model was generated to estimate daclatasvir's dose and schedule to maximize the probability of success for COVID-19.ResultsDaclatasvir inhibited SARS-CoV-2 replication in Vero, HuH-7 and Calu-3 cells, with potencies of 0.8, 0.6 and 1.1 μM, respectively. Although less potent than daclatasvir, sofosbuvir alone and combined with daclatasvir inhibited replication in Calu-3 cells. Sofosbuvir and daclatasvir prevented virus-induced neuronal apoptosis and release of cytokine storm-related inflammatory mediators, respectively. Sofosbuvir inhibited RNA synthesis by chain termination and daclatasvir targeted the folding of secondary RNA structures in the SARS-CoV-2 genome. Concentrations required for partial daclatasvir in vitro activity are achieved in plasma at Cmax after administration of the approved dose to humans.ConclusionsDaclatasvir, alone or in combination with sofosbuvir, at higher doses than used against HCV, may be further fostered as an anti-COVID-19 therapy

Tribute and Resistance: Participation and affective engagement in Brazilian fangame makers and modders’ subscultures

This paper proposes a discussion on particular aspects of production and circulation of Brazilian fangames and mods, in an effort to better comprehend those two growing phenomena as actual subcultures in the Brazilian context. Although not limited to the following characteristics, we assume that fangames are game productions that are not directly related to profit purposes; also, the production of these games is mainly based upon successful mainstream games. From this hypothesis, we observe that fangames and mods are essentially the result of today’s participatory culture, in which tribute and resistance – two concepts that will be properly treated along the paper – are two important engagement forms of the prosumer public

c-di-GMP-related phenotypes are modulated by the interaction between a diguanylate cyclase and a polar hub protein

c-di-GMP is a major player in the switch between biofilm and motile lifestyles. Several bacteria exhibit a large number of c-di-GMP metabolizing proteins, thus a fine-tuning of this nucleotide levels may occur. It is hypothesized that some c-di-GMP metabolizing proteins would provide the global c-di-GMP levels inside the cell whereas others would maintain a localized pool, with the resulting c-di-GMP acting at the vicinity of its production. Although attractive, this hypothesis has yet to be demonstrated in Pseudomonas aeruginosa. We found that the diguanylate cyclase DgcP interacts with the cytosolic region of FimV, a polar peptidoglycan-binding protein involved in type IV pilus assembly. Moreover, DgcP is located at the cell poles in wild type cells but scattered in the cytoplasm of cells lacking FimV. Overexpression of dgcP leads to the classical phenotypes of high c-di-GMP levels (increased biofilm and impaired motilities) in the wild-type strain, but not in a Delta fimV background. Therefore, our findings suggest that DgcP activity is regulated by FimV. The polar localization of DgcP might contribute to a local c-di-GMP pool that can be sensed by other proteins at the cell pole, bringing to light a specialized function for a specific diguanylate cyclase

Highly active antiretroviral therapy for critically ill HIV patients: A systematic review and meta-analysis

<div><p>Introduction</p><p>It is unclear whether the treatment of an HIV infection with highly active antiretroviral therapy (HAART) affects intensive care unit (ICU) outcomes. In this paper, we report the results of a systematic review and meta-analysis performed to summarize the effects of HAART on the prognosis of critically ill HIV positive patients.</p><p>Materials and methods</p><p>A bibliographic search was performed in 3 databases (PubMed, Web of Science and Scopus) to identify articles that investigated the use of HAART during ICU admissions for short- and long-term mortality or survival. Eligible articles were selected in a staged process and were independently assessed by two investigators. The methodological quality of the selected articles was evaluated using the <i>Methodological Index for Non-Randomized Studies</i> (MINORS) tool.</p><p>Results</p><p>Twelve articles met the systematic review inclusion criteria and examined short-term mortality. Six of them also examined long-term mortality (≥90 days) after ICU discharge. The short-term mortality meta-analysis showed a significant beneficial effect of initiating or maintaining HAART during the ICU stay (random effects odds ratio 0.53, p = 0.02). The data analysis of long-term outcomes also suggested a reduced mortality when HAART was used, but the effect of HAART on long-term mortality of HIV positive critically ill patients remains uncertain.</p><p>Conclusions</p><p>This meta-analysis suggests improved survival rates for HIV positive patients who were treated with HAART during their ICU admission.</p></div

Highly active antiretroviral therapy systematic review and meta-analysis flowchart.

<p>HAART systematic review flowchart, which shows the procedure used for the selection of the articles for the qualitative and quantitative synthesis. <i>HAART</i> highly active antiretroviral therapy; <i>ICU</i> intensive care unit. PRISMA Model Flow Diagram [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0186968#pone.0186968.ref024" target="_blank">24</a>].</p

Forest plot of the effects of highly active antiretroviral therapy (HAART) on <i>short-term</i> mortality–random effects odds ratio.

<p>Forest plot of the effects of highly active antiretroviral therapy (HAART) on <i>short-term</i> mortality–random effects odds ratio.</p

Funnel plot of the effects of highly active antiretroviral therapy (HAART) on <i>short-term</i> mortality–random effects odds ratio.

<p>Funnel plot of the effects of highly active antiretroviral therapy (HAART) on <i>short-term</i> mortality–random effects odds ratio.</p

ASSERT trial - How to assess the safety and efficacy of a high frequency rTMS in postpartum depression ? A multicenter, double blinded, randomized, placebo-controlled clinical trial

Background: Postpartum Depression affects a considerable number of women worldwide. This condition inflicts severe consequences to mother and child health. Thus far, available treatments have low response and high relapse rates. We designed this trial to evaluate a safe and more efficacious innovative therapy. Aims: To report a feasible and ethical study design to assess the safety and efficacy of a high frequency repetitive Transcranial Magnetic Stimulation 10 Hz (rTMS) compared to sham rTMS in women with moderate to severe Post-Partum Depression using standard treatment (sertraline). To conduct an ancillary, exploratory, randomized, active controlled, double blind study with a hypothesis to assess the safety and efficacy of 10 Hz rTMS compared to sertraline